Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

BACKGROUND: Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α producing capacity has been shown to be unchanged or reduced when stimulated with a...

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Detalles Bibliográficos
Autores principales: Murayama, Goh, Furusawa, Nanako, Chiba, Asako, Yamaji, Ken, Tamura, Naoto, Miyake, Sachiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649081/
https://www.ncbi.nlm.nih.gov/pubmed/29052537
http://dx.doi.org/10.1186/s13075-017-1441-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649081/
https://www.ncbi.nlm.nih.gov/pubmed/29052537
http://dx.doi.org/10.1186/s13075-017-1441-7

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