Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, I(Kr), underlie SQTS variant 1 (SQT1), in which treatment with Na(+) and K(+) channel blocking class I...

Descripción completa

Detalles Bibliográficos
Autores principales: Whittaker, Dominic G., Ni, Haibo, Benson, Alan P., Hancox, Jules C., Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649182/
https://www.ncbi.nlm.nih.gov/pubmed/29085299
http://dx.doi.org/10.3389/fphys.2017.00759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649182/
https://www.ncbi.nlm.nih.gov/pubmed/29085299
http://dx.doi.org/10.3389/fphys.2017.00759

Ejemplares similares