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Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to...

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Detalles Bibliográficos
Autores principales: Recouvreux, Maria Victoria, Commisso, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649207/
https://www.ncbi.nlm.nih.gov/pubmed/29085336
http://dx.doi.org/10.3389/fendo.2017.00261
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author Recouvreux, Maria Victoria
Commisso, Cosimo
author_facet Recouvreux, Maria Victoria
Commisso, Cosimo
author_sort Recouvreux, Maria Victoria
collection PubMed
description Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to develop novel and more efficient cancer therapies. Macropinocytosis is an evolutionarily conserved endocytic pathway that permits the internalization of extracellular fluid via large endocytic vesicles known as macropinosomes. Recently, macropinocytosis has been determined to function as a nutrient-scavenging pathway in Ras-driven cancer cells. Macropinocytic uptake of extracellular proteins, and their further degradation within endolysosomes, provides the much-needed amino acids that fuel cancer cell metabolism and tumor growth. Here, we review the molecular mechanisms that govern the process of macropinocytosis, as well as discuss recent work that provides evidence of the important role of macropinocytosis as a nutrient supply pathway in cancer cells.
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spelling pubmed-56492072017-10-30 Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer Recouvreux, Maria Victoria Commisso, Cosimo Front Endocrinol (Lausanne) Endocrinology Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to develop novel and more efficient cancer therapies. Macropinocytosis is an evolutionarily conserved endocytic pathway that permits the internalization of extracellular fluid via large endocytic vesicles known as macropinosomes. Recently, macropinocytosis has been determined to function as a nutrient-scavenging pathway in Ras-driven cancer cells. Macropinocytic uptake of extracellular proteins, and their further degradation within endolysosomes, provides the much-needed amino acids that fuel cancer cell metabolism and tumor growth. Here, we review the molecular mechanisms that govern the process of macropinocytosis, as well as discuss recent work that provides evidence of the important role of macropinocytosis as a nutrient supply pathway in cancer cells. Frontiers Media S.A. 2017-09-29 /pmc/articles/PMC5649207/ /pubmed/29085336 http://dx.doi.org/10.3389/fendo.2017.00261 Text en Copyright © 2017 Recouvreux and Commisso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Recouvreux, Maria Victoria
Commisso, Cosimo
Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title_full Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title_fullStr Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title_full_unstemmed Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title_short Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
title_sort macropinocytosis: a metabolic adaptation to nutrient stress in cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649207/
https://www.ncbi.nlm.nih.gov/pubmed/29085336
http://dx.doi.org/10.3389/fendo.2017.00261
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