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Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649207/ https://www.ncbi.nlm.nih.gov/pubmed/29085336 http://dx.doi.org/10.3389/fendo.2017.00261 |
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author | Recouvreux, Maria Victoria Commisso, Cosimo |
author_facet | Recouvreux, Maria Victoria Commisso, Cosimo |
author_sort | Recouvreux, Maria Victoria |
collection | PubMed |
description | Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to develop novel and more efficient cancer therapies. Macropinocytosis is an evolutionarily conserved endocytic pathway that permits the internalization of extracellular fluid via large endocytic vesicles known as macropinosomes. Recently, macropinocytosis has been determined to function as a nutrient-scavenging pathway in Ras-driven cancer cells. Macropinocytic uptake of extracellular proteins, and their further degradation within endolysosomes, provides the much-needed amino acids that fuel cancer cell metabolism and tumor growth. Here, we review the molecular mechanisms that govern the process of macropinocytosis, as well as discuss recent work that provides evidence of the important role of macropinocytosis as a nutrient supply pathway in cancer cells. |
format | Online Article Text |
id | pubmed-5649207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56492072017-10-30 Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer Recouvreux, Maria Victoria Commisso, Cosimo Front Endocrinol (Lausanne) Endocrinology Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a harsh tumor microenvironment. These adaptations might represent metabolic vulnerabilities that can be exploited to develop novel and more efficient cancer therapies. Macropinocytosis is an evolutionarily conserved endocytic pathway that permits the internalization of extracellular fluid via large endocytic vesicles known as macropinosomes. Recently, macropinocytosis has been determined to function as a nutrient-scavenging pathway in Ras-driven cancer cells. Macropinocytic uptake of extracellular proteins, and their further degradation within endolysosomes, provides the much-needed amino acids that fuel cancer cell metabolism and tumor growth. Here, we review the molecular mechanisms that govern the process of macropinocytosis, as well as discuss recent work that provides evidence of the important role of macropinocytosis as a nutrient supply pathway in cancer cells. Frontiers Media S.A. 2017-09-29 /pmc/articles/PMC5649207/ /pubmed/29085336 http://dx.doi.org/10.3389/fendo.2017.00261 Text en Copyright © 2017 Recouvreux and Commisso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Recouvreux, Maria Victoria Commisso, Cosimo Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title | Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title_full | Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title_fullStr | Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title_full_unstemmed | Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title_short | Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer |
title_sort | macropinocytosis: a metabolic adaptation to nutrient stress in cancer |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649207/ https://www.ncbi.nlm.nih.gov/pubmed/29085336 http://dx.doi.org/10.3389/fendo.2017.00261 |
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