Cargando…

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

Peripheral blood leukocytosis has been implicated in promoting tumor progression leading to worse survival, but the mechanisms behind this phenomenon remain unexplored. Here, we examined the prognostic role of pretreatment white blood cell (WBC) count and clinicopathologic parameters in the context...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Daniel, Rödel, Franz, Winkelmann, Ria, Balermpas, Panagiotis, Rödel, Claus, Fokas, Emmanouil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649213/ https://www.ncbi.nlm.nih.gov/pubmed/29085358 http://dx.doi.org/10.3389/fimmu.2017.01225

Ejemplares similares

C-Reactive Protein-to-Albumin Ratio as Prognostic Marker for Anal Squamous Cell Carcinoma Treated With Chemoradiotherapy
por: Martin, Daniel, et al.
Publicado: (2019)

Merkel Cell Polyoma Viral Load and Intratumoral CD8+ Lymphocyte Infiltration Predict Overall Survival in Patients With Merkel Cell Carcinoma
por: von der Grün, Jens, et al.
Publicado: (2019)

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy
por: Rödel, Franz, et al.
Publicado: (2016)

Sarcopenia Is Associated With Hematologic Toxicity During Chemoradiotherapy in Patients With Anal Carcinoma
por: Martin, Daniel, et al.
Publicado: (2020)

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
por: Balermpas, P, et al.
Publicado: (2014)

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
por: Balermpas, P, et al.
Publicado: (2014)

Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go?
por: von der Grün, Jens, et al.
Publicado: (2019)

Complete response after chemoradiotherapy for rectal cancer: what is the reasonable approach?
por: Rödel, Claus, et al.
Publicado: (2017)

Management of anal cancer patients – a pattern of care analysis in German-speaking countries
por: Martin, Daniel, et al.
Publicado: (2020)

High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy
por: Fraunholz, Ingeborg, et al.
Publicado: (2012)

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer—A Promising Signaling Network for Therapeutic Interventions
por: Güllülü, Ömer, et al.
Publicado: (2021)

Definitive, Preoperative, and Palliative Radiation Therapy of Esophageal Cancer
por: Fokas, Emmanouil, et al.
Publicado: (2015)

Präoperative Therapie des Rektumkarzinoms – Kritische Anmerkungen zur amerikanischen PROSPECT-Studie
por: Fokas, Emmanouil, et al.
Publicado: (2023)

Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial
por: von der Grün, Jens, et al.
Publicado: (2022)

Chemoradiotherapy as Definitive Treatment for Elderly Patients with Head and Neck Cancer
por: Müller von der Grün, Jens, et al.
Publicado: (2018)

ACO/ARO/AIO-21 - Capecitabine-based chemoradiotherapy in combination with the IL-1 receptor antagonist anakinra for rectal cancer Patients: A phase I trial of the German rectal cancer study group
por: Fleischmann, Maximilian, et al.
Publicado: (2022)

Re-irradiation with concurrent and maintenance nivolumab in locally recurrent and inoperable squamous cell carcinoma of the head and neck: A single-center cohort study
por: Altay-Langguth, Alev, et al.
Publicado: (2021)

C-Reactive Protein to Albumin Ratio as Prognostic Marker in Locally Advanced Non-Small Cell Lung Cancer Treated with Chemoradiotherapy
por: Frey, Alina, et al.
Publicado: (2022)

Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center
por: von der Grün, Jens, et al.
Publicado: (2021)

Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences
por: Balermpas, P, et al.
Publicado: (2014)

Baseline Peripheral Blood Leukocytosis Is Negatively Correlated With T-Cell Infiltration Predicting Worse Outcome in Colorectal Cancers
por: Hu, Xiang, et al.
Publicado: (2018)

Kurzzeitstrahlentherapie mit 5 × 5 Gy gefolgt von präoperativer Chemotherapie und Resektion bei Patienten mit lokal fortgeschrittenen Rektumkarzinomen führt zu einer Verbesserung des krankheitsfreien Überlebens
por: Kirste, Simon, et al.
Publicado: (2021)

Kein Vorteil für die lokale Kontrolle nach Dosiseskalation der Strahlentherapie bei Patienten mit Ösophaguskarzinom nach einer definitiven Radiochemotherapie: randomisierte Phase-III-Studie ARTDECO
por: Fokas, Emmanouil, et al.
Publicado: (2022)

Eine Monotherapie mit Immuncheckpointblockade führt bei Patienten mit Rektumkarzinom und Mikrosatelliteninstabilität zur klinischen Komplettremission
por: Diefenhardt, Markus, et al.
Publicado: (2022)

Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1
por: Freund, Isabel, et al.
Publicado: (2020)

Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib
por: Hehlgans, Stephanie, et al.
Publicado: (2018)

Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer
por: Fleischmann, Maximilian, et al.
Publicado: (2021)

Preoperative leukocytosis is associated with increased tumor-infiltrating neutrophil extracellular traps and worse outcomes in esophageal cancer
por: Zhang, Hao, et al.
Publicado: (2020)

RADIANCE – Radiochemotherapy with or without Durvalumab in the treatment of anal squamous cell carcinoma: A randomized multicenter phase II trial
por: Martin, Daniel, et al.
Publicado: (2020)

Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy
por: Fleischmann, Maximilian, et al.
Publicado: (2022)

Image-guided radiotherapy in an orthotopic mouse model of rectal cancer
por: Nicolas, Adele M., et al.
Publicado: (2022)

Heat shock protein 70 and tumor‐infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG)
por: Stangl, Stefan, et al.
Publicado: (2017)

Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial
por: Diefenhardt, Markus, et al.
Publicado: (2022)

Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site – current status and challenges
por: Müller von der Grün, Jens, et al.
Publicado: (2017)

Overall Survival After Treatment Failure Among Patients With Rectal Cancer
por: Diefenhardt, Markus, et al.
Publicado: (2023)

Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy
por: Fleischmann, Max, et al.
Publicado: (2019)

Patterns of care analysis for salivary gland cancer: a survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice
por: von der Grün, Jens, et al.
Publicado: (2021)

Neoadjuvant chemoradiation versus perioperative chemotherapy followed by surgery in resectable adenocarcinomas of the esophagogastric junction: A retrospective single center analysis
por: SCHULZE, BJÖRN, et al.
Publicado: (2014)

Risk stratification by anamnesis increases SARS-CoV-2 test efficiency in cancer patients
por: Arnold, Christian Cornelius, et al.
Publicado: (2021)

Image-guided high-dose-rate brachytherapy for rectal cancer: technical note and first clinical experience on an organ-preserving approach
por: Fleischmann, Maximilian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6karr4cjcellej9jifi2a4n2t8