One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes because of pleiotropic effects, including the regulation of islet hormones and the induction of satiety. However, the native ligand for the GLP1 receptor has a short half-live owing to enzym...

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Detalles Bibliográficos
Autores principales: Luginbuhl, Kelli M., Schaal, Jeffrey L., Umstead, Bret, Mastria, Eric M., Li, Xinghai, Banskota, Samagya, Arnold, Susan, Feinglos, Mark, D’Alessio, David, Chilkoti, Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650111/
https://www.ncbi.nlm.nih.gov/pubmed/29062587
http://dx.doi.org/10.1038/s41551-017-0078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650111/
https://www.ncbi.nlm.nih.gov/pubmed/29062587
http://dx.doi.org/10.1038/s41551-017-0078

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