Cargando…
GATA2 deficiency and related myeloid neoplasms
The GATA2 gene codes for a hematopoietic transcription factor that through its two zinc fingers (ZF) can occupy GATA-DNA motifs in a countless number of genes. It is crucial for the proliferation and maintenance of hematopoietic stem cells. During the past 5 years, germline heterozygous mutations in...
Autores principales: | Wlodarski, Marcin W., Collin, Matthew, Horwitz, Marshall S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650112/ https://www.ncbi.nlm.nih.gov/pubmed/28637621 http://dx.doi.org/10.1053/j.seminhematol.2017.05.002 |
Ejemplares similares
-
Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes
por: Sahoo, Sushree S., et al.
Publicado: (2020) -
Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations
por: Mir, Muhammad A, et al.
Publicado: (2015) -
GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1
por: Singh, Preeti, et al.
Publicado: (2021) -
Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency
por: Kozyra, Emilia J., et al.
Publicado: (2020) -
GATA2 deficiency and MDS/AML: Experimental strategies for disease modelling and future therapeutic prospects
por: Kotmayer, Lili, et al.
Publicado: (2022)