GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent

GPR40 agonists are effective antidiabetic agents believed to lower glucose through direct effects on the beta cell to increase glucose stimulated insulin secretion. However, not all GPR40 agonists are the same. Partial agonists lower glucose through direct effects on the pancreas, whereas GPR40 AgoP...

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Detalles Bibliográficos
Autores principales: Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W., Chobanian, Harry R., Miller, Michael W., Souza, Sarah, Thomas-Fowlkes, Brande S., Ogawa, Aimie M., Weinglass, Adam B., Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A., Howard, Andrew D., Colletti, Steven L., Trujillo, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650142/
https://www.ncbi.nlm.nih.gov/pubmed/29053717
http://dx.doi.org/10.1371/journal.pone.0186033

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