Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor

The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164(th) position in β2AR and results in receptor sequestration and altered binding of agonists. Present investigation pursues to identify the effect of T164I variation on function and structure of β2AR through...

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Detalles Bibliográficos
Autores principales: Bandaru, Srinivas, Alvala, Mallika, Nayarisseri, Anuraj, Sharda, Saphy, Goud, Himshikha, Mundluru, Hema Prasad, Singh, Sanjeev Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650161/
https://www.ncbi.nlm.nih.gov/pubmed/29053759
http://dx.doi.org/10.1371/journal.pone.0186666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650161/
https://www.ncbi.nlm.nih.gov/pubmed/29053759
http://dx.doi.org/10.1371/journal.pone.0186666

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