Cargando…
Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor
The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164(th) position in β2AR and results in receptor sequestration and altered binding of agonists. Present investigation pursues to identify the effect of T164I variation on function and structure of β2AR through...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650161/ https://www.ncbi.nlm.nih.gov/pubmed/29053759 http://dx.doi.org/10.1371/journal.pone.0186666 |