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Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion
The anti-diabetic metformin has been demonstrated to be effective in suppression of tumor progression via multiple mechanisms, in which angiogenic inhibition is involved. Hypoxia is a common feather of malignant tumor and promotes angiogenesis via induction of pro-angiogenic factors. However, the ef...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650310/ https://www.ncbi.nlm.nih.gov/pubmed/29088755 http://dx.doi.org/10.18632/oncotarget.18029 |