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Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion

BACKGROUND: Vascular cognitive impairment (VCI) is a spectrum of cognitive impairment caused by various chronic diseases including aging, hypertension, and diabetes mellitus. Oxidative and inflammatory reactions induced by chronic cerebral hypoperfusion (CHP) are believed to cause VCI. Melatonin is...

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Detalles Bibliográficos
Autores principales: Tsai, Tzu-Hsien, Lin, Cheng-Jei, Chua, Sarah, Chung, Sheng-Ying, Yang, Cheng-Hsu, Tong, Meng-Shen, Hang, Chi-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650343/
https://www.ncbi.nlm.nih.gov/pubmed/29088788
http://dx.doi.org/10.18632/oncotarget.20382