CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro

CC-115, a selective dual inhibitor of the mammalian target of rapamycin (mTOR) kinase and DNA-dependent protein kinase (DNA-PK), is undergoing Phase 1 clinical studies. Here we report the characterization of DNA-PK inhibitory activity of CC-115 in cancer cell lines. CC-115 inhibits auto-phosphorylat...

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Detalles Bibliográficos
Autores principales: Tsuji, Toshiya, Sapinoso, Lisa M., Tran, Tam, Gaffney, Bonny, Wong, Lilly, Sankar, Sabita, Raymon, Heather K., Mortensen, Deborah S., Xu, Shuichan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650372/
https://www.ncbi.nlm.nih.gov/pubmed/29088817
http://dx.doi.org/10.18632/oncotarget.20342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650372/
https://www.ncbi.nlm.nih.gov/pubmed/29088817
http://dx.doi.org/10.18632/oncotarget.20342

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