KRAS-driven miR-29b expression is required for tumor suppressor gene silencing

KRAS activation drives DNA methylation and silencing of specific tumor suppressor genes (TSGs). We previously showed that the ERK pathway induces transcriptional repression of TET1, which results in conversion of TSG promoters from a hydroxymethylated, active state to a hypermethylated and silenced...

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Detalles Bibliográficos
Autores principales: Thakur, Shilpa, Brenner, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650376/
https://www.ncbi.nlm.nih.gov/pubmed/29088821
http://dx.doi.org/10.18632/oncotarget.20364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650376/
https://www.ncbi.nlm.nih.gov/pubmed/29088821
http://dx.doi.org/10.18632/oncotarget.20364

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