Ligand modulation of sidechain dynamics in a wild-type human GPCR

GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transitions between GPCR conformations. To address this...

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Detalles Bibliográficos
Autores principales: Clark, Lindsay D, Dikiy, Igor, Chapman, Karen, Rödström, Karin EJ, Aramini, James, LeVine, Michael V, Khelashvili, George, Rasmussen, Søren GF, Gardner, Kevin H, Rosenbaum, Daniel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650471/
https://www.ncbi.nlm.nih.gov/pubmed/28984574
http://dx.doi.org/10.7554/eLife.28505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650471/
https://www.ncbi.nlm.nih.gov/pubmed/28984574
http://dx.doi.org/10.7554/eLife.28505

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