Ptpn11 Deletion in CD4(+) Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner

The ubiquitously expressed tyrosine phosphatase Src homology region 2 domain-containing phosphatase-2 (SHP-2, encoded by Ptpn11) is required for constitutive cellular processes including proliferation, differentiation, and the regulation of immune responses. During development and maturation, subset...

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Detalles Bibliográficos
Autores principales: Miah, S. M. Shahjahan, Jayasuriya, Chathuraka T., Salter, Alexander I., Reilly, Emma C., Fugere, Céline, Yang, Wentian, Chen, Qian, Brossay, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650614/
https://www.ncbi.nlm.nih.gov/pubmed/29085371
http://dx.doi.org/10.3389/fimmu.2017.01326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650614/
https://www.ncbi.nlm.nih.gov/pubmed/29085371
http://dx.doi.org/10.3389/fimmu.2017.01326

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