Cargando…

Ptpn11 Deletion in CD4(+) Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner

The ubiquitously expressed tyrosine phosphatase Src homology region 2 domain-containing phosphatase-2 (SHP-2, encoded by Ptpn11) is required for constitutive cellular processes including proliferation, differentiation, and the regulation of immune responses. During development and maturation, subset...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miah, S. M. Shahjahan, Jayasuriya, Chathuraka T., Salter, Alexander I., Reilly, Emma C., Fugere, Céline, Yang, Wentian, Chen, Qian, Brossay, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650614/ https://www.ncbi.nlm.nih.gov/pubmed/29085371 http://dx.doi.org/10.3389/fimmu.2017.01326

Ejemplares similares

Ptpn11 Deletion in A Novel Cartilage Cell Causes Metachondromatosis by Activating Hedgehog Signaling
por: Yang, Wentian, et al.
Publicado: (2013)

SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism
por: McNamara, Jeffrey T., et al.
Publicado: (2021)

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
por: Ventura, Pedro M O, et al.
Publicado: (2022)

Role of Type I Interferon Receptor Signaling on NK Cell Development and Functions
por: Guan, Jean, et al.
Publicado: (2014)

Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage
por: Liu, Wenguang, et al.
Publicado: (2021)

Suppressing Chondrocyte Hypertrophy to Build Better Cartilage
por: Shigley, Christian, et al.
Publicado: (2023)

Molecular characterization of mesenchymal stem cells in human osteoarthritis cartilage reveals contribution to the OA phenotype
por: Jayasuriya, Chathuraka T., et al.
Publicado: (2018)

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair
por: Desai, Salomi, et al.
Publicado: (2020)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
por: Niogret, Charlène, et al.
Publicado: (2019)

Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis
por: Wang, Lijun, et al.
Publicado: (2021)

Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression
por: Zhang, Jingru, et al.
Publicado: (2023)

Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR
por: Hu, Nan, et al.
Publicado: (2019)

Stable human cartilage progenitor cell line stimulates healing of meniscal tears and attenuates post-traumatic osteoarthritis
por: Desai, Salomi, et al.
Publicado: (2022)

From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis
por: Yang, Wentian, et al.
Publicado: (2013)

Salivary Gland NK Cells Are Phenotypically and Functionally Unique
por: Tessmer, Marlowe S., et al.
Publicado: (2011)

Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers
por: Tata, Angela, et al.
Publicado: (2021)

PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion
por: Knipper, Johanna A., et al.
Publicado: (2020)

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
por: Griger, Joscha, et al.
Publicado: (2017)

Deletion of PTPN22 improves effector and memory CD8(+) T cell responses to tumors
por: Brownlie, Rebecca J., et al.
Publicado: (2019)

MON-262 Aggrecan Is Required for Chondrocyte Differentiation in ATDC5 Chondroprogenitor Cells
por: Hodax, Juanita, et al.
Publicado: (2019)

Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation
por: Harigai, Ritsuko, et al.
Publicado: (2022)

Qa-1-Restricted CD8(+) T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection
por: Anderson, Courtney K., et al.
Publicado: (2019)

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
por: Wiede, Florian, et al.
Publicado: (2019)

MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9
por: Ma, Xiaoping, et al.
Publicado: (2018)

The Murine Nonclassical Class I Major Histocompatibility Complex–like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis
por: Chang, Chew Shun, et al.
Publicado: (1999)

Rare copy number variations containing genes involved in RASopathies: deletion of SHOC2 and duplication of PTPN11
por: Chen, Jin-Lan, et al.
Publicado: (2014)

Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells
por: Hodax, Juanita K., et al.
Publicado: (2019)

Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review
por: Trivedi, Jay, et al.
Publicado: (2021)

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
por: Bray, Cara, et al.
Publicado: (2018)

Activated iNKT Cells Promote Memory CD8(+) T Cell Differentiation during Viral Infection
por: Reilly, Emma C., et al.
Publicado: (2012)

PTK2 and PTPN11 expression in myelodysplastic syndromes
por: Lazarini, Mariana, et al.
Publicado: (2013)

PTPN11 hypomethylation is associated with gastric cancer progression
por: Xu, Lele, et al.
Publicado: (2020)

Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression
por: Jayasuriya, Chathuraka T, et al.
Publicado: (2012)

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice
por: Chen, Yupeng, et al.
Publicado: (2016)

Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells
por: Jayasuriya, Chathuraka T., et al.
Publicado: (2014)

Human Cartilage‐Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears
por: Jayasuriya, Chathuraka T., et al.
Publicado: (2018)

miR-186 Inhibits Liver Cancer Stem Cells Expansion via Targeting PTPN11
por: Yao, Haochen, et al.
Publicado: (2021)

Distinct and Overlapping Functions of ptpn11 Genes in Zebrafish Development
por: Bonetti, Monica, et al.
Publicado: (2014)

Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice
por: Usenko, Tatiana, et al.
Publicado: (2014)

Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas
por: Takada, Marilia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vbkmk9o985lauj1t860p1kvr02