Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening

Loss of function of dyskerin (DKC1), NOP10 and TIN2 are responsible for different inheritance patterns of Dyskeratosis congenita (DC; ORPHA1775). They are key components of telomerase (DKC1 and NOP10) and shelterin (TIN2), and play an important role in telomere homeostasis. They participate in sever...

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Detalles Bibliográficos
Autores principales: Ibáñez-Cabellos, José Santiago, Pérez-Machado, Giselle, Seco-Cervera, Marta, Berenguer-Pascual, Ester, García-Giménez, José Luis, Pallardó, Federico V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650655/
https://www.ncbi.nlm.nih.gov/pubmed/29055871
http://dx.doi.org/10.1016/j.redox.2017.10.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650655/
https://www.ncbi.nlm.nih.gov/pubmed/29055871
http://dx.doi.org/10.1016/j.redox.2017.10.004

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