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The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction
Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic or leukemic stem cells (HSC and LSC). The physiological oxygen concentration in tissues ranges between 0.1 and 5.0%. Stem cell niches (SCN)...
Autores principales: | Cheloni, Giulia, Poteti, Martina, Bono, Silvia, Masala, Erico, Mazure, Nathalie M., Rovida, Elisabetta, Lulli, Matteo, Dello Sbarba, Persio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651121/ https://www.ncbi.nlm.nih.gov/pubmed/29118813 http://dx.doi.org/10.1155/2017/4979474 |
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