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PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line

Inner ear hair cell death leads to sensorineural hearing loss and can be a direct consequence of aminoglycoside antibiotic treatment. Aminoglycosides such as gentamicin are effective therapy for serious Gram-negative bacterial infections such as some forms of meningitis, pneumonia, and sepsis. Amino...

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Detalles Bibliográficos
Autores principales: Wiedenhoft, Heather, Hayashi, Lauren, Coffin, Allison B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651234/
https://www.ncbi.nlm.nih.gov/pubmed/29093665
http://dx.doi.org/10.3389/fncel.2017.00326