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Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes

At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive immune responses, ultimately resulting in a loss o...

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Detalles Bibliográficos
Autores principales:	Wallet, Mark A., Santostefano, Katherine E., Terada, Naohiro, Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651267/ https://www.ncbi.nlm.nih.gov/pubmed/29093700 http://dx.doi.org/10.3389/fendo.2017.00276

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