The effects of advanced age and serum α(1)‐acid glycoprotein on docetaxel unbound exposure and dose‐limiting toxicity in cancer patients

AIM: α(1)‐Acid glycoprotein (AAG), which is a major binding protein of docetaxel, is considered to be a determinant for docetaxel pharmacokinetics. However, there are no reports about the impact of serum AAG on pharmacokinetics and pharmacodynamics in elderly patients treated with docetaxel. The aim...

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Detalles Bibliográficos
Autores principales: Kenmotsu, Hirotsugu, Imamura, Chiyo K., Ono, Akira, Omori, Shota, Nakashima, Kazuhisa, Wakuda, Kazushige, Taira, Tetsuhiko, Naito, Tateaki, Murakami, Haruyasu, Takahashi, Toshiaki, Tanigawara, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651322/
https://www.ncbi.nlm.nih.gov/pubmed/28640540
http://dx.doi.org/10.1111/bcp.13354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651322/
https://www.ncbi.nlm.nih.gov/pubmed/28640540
http://dx.doi.org/10.1111/bcp.13354

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