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The effects of advanced age and serum α(1)‐acid glycoprotein on docetaxel unbound exposure and dose‐limiting toxicity in cancer patients
AIM: α(1)‐Acid glycoprotein (AAG), which is a major binding protein of docetaxel, is considered to be a determinant for docetaxel pharmacokinetics. However, there are no reports about the impact of serum AAG on pharmacokinetics and pharmacodynamics in elderly patients treated with docetaxel. The aim...
Autores principales: | Kenmotsu, Hirotsugu, Imamura, Chiyo K., Ono, Akira, Omori, Shota, Nakashima, Kazuhisa, Wakuda, Kazushige, Taira, Tetsuhiko, Naito, Tateaki, Murakami, Haruyasu, Takahashi, Toshiaki, Tanigawara, Yusuke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651322/ https://www.ncbi.nlm.nih.gov/pubmed/28640540 http://dx.doi.org/10.1111/bcp.13354 |
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