SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy

INTRODUCTION: Tau hyperphosphorylation and neurofibrillary tangles are histopathologic hallmarks of tauopathies. Histamine H3-receptor antagonists have been proposed to reduce tau hyperphosphorylation in preclinical models. METHODS: We evaluated the ability of SAR110894, a selective histamine H3-rec...

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Detalles Bibliográficos
Autores principales: Delay-Goyet, Philippe, Blanchard, Véronique, Schussler, Nathalie, Lopez-Grancha, Mati, Ménager, Jean, Mary, Véronique, Sultan, Eric, Buzy, Armelle, Guillemot, Jean-Claude, Stemmelin, Jeanne, Bertrand, Philippe, Rooney, Thomas, Pradier, Laurent, Barnéoud, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651361/
https://www.ncbi.nlm.nih.gov/pubmed/29067314
http://dx.doi.org/10.1016/j.trci.2016.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651361/
https://www.ncbi.nlm.nih.gov/pubmed/29067314
http://dx.doi.org/10.1016/j.trci.2016.10.002

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