TNFR1 inhibition with a Nanobody protects against EAE development in mice

TNF has as detrimental role in multiple sclerosis (MS), however, anti-TNF medication is not working. Selective TNF/TNFR1 inhibition whilst sparing TNFR2 signaling reduces the pro-inflammatory effects of TNF but preserves the important neuroprotective signals via TNFR2. We previously reported the gen...

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Detalles Bibliográficos
Autores principales: Steeland, Sophie, Van Ryckeghem, Sara, Van Imschoot, Griet, De Rycke, Riet, Toussaint, Wendy, Vanhoutte, Leen, Vanhove, Christian, De Vos, Filip, Vandenbroucke, Roosmarijn E., Libert, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651799/
https://www.ncbi.nlm.nih.gov/pubmed/29057962
http://dx.doi.org/10.1038/s41598-017-13984-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651799/
https://www.ncbi.nlm.nih.gov/pubmed/29057962
http://dx.doi.org/10.1038/s41598-017-13984-y

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