ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells

Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilizatio...

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Detalles Bibliográficos
Autores principales: Guerra, Fabiana Sélos, Oliveira, Ramon Guerra de, Fraga, Carlos Alberto Manssour, Mermelstein, Claudia dos Santos, Fernandes, Patricia Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651822/
https://www.ncbi.nlm.nih.gov/pubmed/29057980
http://dx.doi.org/10.1038/s41598-017-14216-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651822/
https://www.ncbi.nlm.nih.gov/pubmed/29057980
http://dx.doi.org/10.1038/s41598-017-14216-z

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