Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

The human shelterin proteins associate with telomeric DNA to confer telomere protection and length regulation. They are thought to form higher-order protein complexes for their functions, but studies of shelterin proteins have been mostly limited to pairs of proteins. Here we co-express various huma...

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Detalles Bibliográficos
Autores principales: Lim, Ci Ji, Zaug, Arthur J., Kim, Hee Jin, Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651854/
https://www.ncbi.nlm.nih.gov/pubmed/29057866
http://dx.doi.org/10.1038/s41467-017-01313-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651854/
https://www.ncbi.nlm.nih.gov/pubmed/29057866
http://dx.doi.org/10.1038/s41467-017-01313-w

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