The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis

Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the interaction of Int3 wit...

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Detalles Bibliográficos
Autores principales: Raafat, Ahmed, Bargo, Sharon, McCurdy, David, Callahan, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651869/
https://www.ncbi.nlm.nih.gov/pubmed/29057904
http://dx.doi.org/10.1038/s41598-017-13989-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651869/
https://www.ncbi.nlm.nih.gov/pubmed/29057904
http://dx.doi.org/10.1038/s41598-017-13989-7

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