Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice

Gpbar1 is a bile acid activated receptor for secondary bile acids. Here we have investigated the mechanistic role of Gpbar1 in the regulation of adipose tissues functionality in a murine model of steatohepatitis (NASH). Feeding wild type and Gpbar1(−/−) mice with a high fat diet-fructose (HFD-F) lea...

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Detalles Bibliográficos
Autores principales: Carino, Adriana, Cipriani, Sabrina, Marchianò, Silvia, Biagioli, Michele, Scarpelli, Paolo, Zampella, Angela, Monti, Maria Chiara, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651899/
https://www.ncbi.nlm.nih.gov/pubmed/29057935
http://dx.doi.org/10.1038/s41598-017-13102-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651899/
https://www.ncbi.nlm.nih.gov/pubmed/29057935
http://dx.doi.org/10.1038/s41598-017-13102-y

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