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Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

Cytoplasmic aggregation of fused in sarcoma (FUS) is detected in brain regions affected by amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which compose the disease spectrum, FUS proteinopathy. To understand the pathomechanism of ALS-FTD-associated FUS, we examined the behavio...

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Detalles Bibliográficos
Autores principales: Shiihashi, Gen, Ito, Daisuke, Arai, Itaru, Kobayashi, Yuki, Hayashi, Kanehiro, Otsuka, Shintaro, Nakajima, Kazunori, Yuzaki, Michisuke, Itohara, Shigeyoshi, Suzuki, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652009/
https://www.ncbi.nlm.nih.gov/pubmed/28928015
http://dx.doi.org/10.1016/j.ebiom.2017.09.005