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Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland

Factor H autoantibodies can impair complement regulation, resulting in atypical hemolytic uremic syndrome, predominantly in childhood. There are no trials investigating treatment, and clinical practice is only informed by retrospective cohort analysis. Here we examined 175 children presenting with a...

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Detalles Bibliográficos
Autores principales: Brocklebank, Vicky, Johnson, Sally, Sheerin, Thomas P., Marks, Stephen D., Gilbert, Rodney D., Tyerman, Kay, Kinoshita, Meredith, Awan, Atif, Kaur, Amrit, Webb, Nicholas, Hegde, Shivaram, Finlay, Eric, Fitzpatrick, Maggie, Walsh, Patrick R., Wong, Edwin K.S., Booth, Caroline, Kerecuk, Larissa, Salama, Alan D., Almond, Mike, Inward, Carol, Goodship, Timothy H., Sheerin, Neil S., Marchbank, Kevin J., Kavanagh, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652378/
https://www.ncbi.nlm.nih.gov/pubmed/28750931
http://dx.doi.org/10.1016/j.kint.2017.04.028