High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This su...

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Autores principales: Guo, Yan, Tomich, Adam D., McElheny, Christi L., Cooper, Vaughn S., Tait-Kamradt, Amelia, Wang, Minggui, Hu, Fupin, Rice, Louis B., Sluis-Cremer, Nicolas, Doi, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652432/
https://www.ncbi.nlm.nih.gov/pubmed/29048285
http://dx.doi.org/10.3201/eid2311.171130
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author Guo, Yan
Tomich, Adam D.
McElheny, Christi L.
Cooper, Vaughn S.
Tait-Kamradt, Amelia
Wang, Minggui
Hu, Fupin
Rice, Louis B.
Sluis-Cremer, Nicolas
Doi, Yohei
author_facet Guo, Yan
Tomich, Adam D.
McElheny, Christi L.
Cooper, Vaughn S.
Tait-Kamradt, Amelia
Wang, Minggui
Hu, Fupin
Rice, Louis B.
Sluis-Cremer, Nicolas
Doi, Yohei
author_sort Guo, Yan
collection PubMed
description Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
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spelling pubmed-56524322017-11-01 High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium Guo, Yan Tomich, Adam D. McElheny, Christi L. Cooper, Vaughn S. Tait-Kamradt, Amelia Wang, Minggui Hu, Fupin Rice, Louis B. Sluis-Cremer, Nicolas Doi, Yohei Emerg Infect Dis Dispatch Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays. Centers for Disease Control and Prevention 2017-11 /pmc/articles/PMC5652432/ /pubmed/29048285 http://dx.doi.org/10.3201/eid2311.171130 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Guo, Yan
Tomich, Adam D.
McElheny, Christi L.
Cooper, Vaughn S.
Tait-Kamradt, Amelia
Wang, Minggui
Hu, Fupin
Rice, Louis B.
Sluis-Cremer, Nicolas
Doi, Yohei
High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title_full High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title_fullStr High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title_full_unstemmed High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title_short High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
title_sort high-level fosfomycin resistance in vancomycin-resistant enterococcus faecium
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652432/
https://www.ncbi.nlm.nih.gov/pubmed/29048285
http://dx.doi.org/10.3201/eid2311.171130
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