Cargando…
Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis
Decorin (DCN) is a small leucine-rich proteoglycan that plays an important role in the regulation of apoptosis, proliferation, intercellular contact, and cell migration. Here we have investigated the detailed mechanism of apoptotic cell death induced by DCN expression. A marked increase in cytotoxic...
Autores principales: | Yoon, A-Rum, Hong, JinWoo, Yun, Chae-Ok |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652734/ https://www.ncbi.nlm.nih.gov/pubmed/29100340 http://dx.doi.org/10.18632/oncotarget.20800 |
Ejemplares similares
-
Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model
por: Oh, Eonju, et al.
Publicado: (2016) -
Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions
por: Yoon, A-Rum, et al.
Publicado: (2018) -
Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses
por: Thambi, Thavasyappan, et al.
Publicado: (2022) -
ErbB3-Targeting Oncolytic Adenovirus Causes Potent Tumor Suppression by Induction of Apoptosis in Cancer Cells
por: Jung, Bo-Kyeong, et al.
Publicado: (2022) -
A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth
por: Yoon, A-Rum, et al.
Publicado: (2015)