Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization

p21-activated kinase 4 (PAK4) regulates cell proliferation, apoptosis, cell motility and F-actin remodeling, but the PAK4 interactome has not been systematically analyzed. Here, we comprehensively characterized the human PAK4 interactome by iTRAQ quantitative mass spectrometry of PAK4-immunoprecipit...

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Detalles Bibliográficos
Autores principales: Zhao, Miao, Spiess, Matthias, Johansson, Henrik J., Olofsson, Helene, Hu, Jianjiang, Lehtiö, Janne, Strömblad, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652764/
https://www.ncbi.nlm.nih.gov/pubmed/29100370
http://dx.doi.org/10.18632/oncotarget.20352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652764/
https://www.ncbi.nlm.nih.gov/pubmed/29100370
http://dx.doi.org/10.18632/oncotarget.20352

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