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Sitagliptin attenuates high glucose-induced alterations in migration, proliferation, calcification and apoptosis of vascular smooth muscle cells through ERK1/2 signal pathway

BACKGROUND/AIMS: This study investigated the effects of sitagliptin on migration, proliferation, calcification and apoptosis of vascular smooth muscle cells (VSMCs) under high glucose (HG) conditions. METHODS: VSMCs were isolated from the thoracic aorta of Sprague Dawley rats. The cultured VSMCs wer...

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Detalles Bibliográficos
Autores principales: Shi, Lili, Ji, Ye, Liu, Dandan, Liu, Ying, Xu, Ying, Cao, Yang, Jiang, Xiaoyan, Xu, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652771/
https://www.ncbi.nlm.nih.gov/pubmed/29100378
http://dx.doi.org/10.18632/oncotarget.20417