The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells

Microtubule-targeting agents (MTAs) are the most widely used chemotherapeutic drugs. Pretubulysin (PT), a biosynthetic precursor of the myxobacterial tubulysins, was recently identified as a novel MTA. Besides its strong anti-tumoral activities, PT attenuates tumor angiogenesis, exerts anti-vascular...

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Detalles Bibliográficos
Autores principales: Schwenk, Rebecca, Stehning, Tanja, Bischoff, Iris, Ullrich, Angelika, Kazmaier, Uli, Fürst, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652804/
https://www.ncbi.nlm.nih.gov/pubmed/29100413
http://dx.doi.org/10.18632/oncotarget.20746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652804/
https://www.ncbi.nlm.nih.gov/pubmed/29100413
http://dx.doi.org/10.18632/oncotarget.20746

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