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Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant
We have previously engineered new RNase P-based ribozyme variants with improved in vitro catalytic activity. In this study, we employed a novel engineered variant to target a shared mRNA region of human cytomegalovirus (HCMV) immediate early proteins 1 (IE1) and 2 (IE2), which are essential for the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653336/ https://www.ncbi.nlm.nih.gov/pubmed/29059242 http://dx.doi.org/10.1371/journal.pone.0186791 |