Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

Current strategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries. Here we present a strategy to produce site-specific ADCs using a highly reactive natural buried lysine embedded in a dual variable domain (DVD) format. This approach is...

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Detalles Bibliográficos
Autores principales: Nanna, Alex R., Li, Xiuling, Walseng, Even, Pedzisa, Lee, Goydel, Rebecca S., Hymel, David, Burke Jr., Terrence R., Roush, William R., Rader, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653646/
https://www.ncbi.nlm.nih.gov/pubmed/29062027
http://dx.doi.org/10.1038/s41467-017-01257-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653646/
https://www.ncbi.nlm.nih.gov/pubmed/29062027
http://dx.doi.org/10.1038/s41467-017-01257-1

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