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Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
Current strategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries. Here we present a strategy to produce site-specific ADCs using a highly reactive natural buried lysine embedded in a dual variable domain (DVD) format. This approach is...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653646/ https://www.ncbi.nlm.nih.gov/pubmed/29062027 http://dx.doi.org/10.1038/s41467-017-01257-1 |