Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease

Pompe disease, a rare lysosomal storage disease caused by deficiency of the lysosomal acid α-glucosidase (GAA), is characterized by glycogen accumulation, triggering severe secondary cellular damage and resulting in progressive motor handicap and premature death. Numerous disease-causing mutations i...

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Detalles Bibliográficos
Autores principales: Roig-Zamboni, Véronique, Cobucci-Ponzano, Beatrice, Iacono, Roberta, Ferrara, Maria Carmina, Germany, Stanley, Bourne, Yves, Parenti, Giancarlo, Moracci, Marco, Sulzenbacher, Gerlind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653652/
https://www.ncbi.nlm.nih.gov/pubmed/29061980
http://dx.doi.org/10.1038/s41467-017-01263-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653652/
https://www.ncbi.nlm.nih.gov/pubmed/29061980
http://dx.doi.org/10.1038/s41467-017-01263-3

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