Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice

Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored. Here, we probed the consequences of mGluR5/Homer scaffold d...

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Detalles Bibliográficos
Autores principales: Aloisi, Elisabetta, Le Corf, Katy, Dupuis, Julien, Zhang, Pei, Ginger, Melanie, Labrousse, Virginie, Spatuzza, Michela, Georg Haberl, Matthias, Costa, Lara, Shigemoto, Ryuichi, Tappe-Theodor, Anke, Drago, Filippo, Vincenzo Piazza, Pier, Mulle, Christophe, Groc, Laurent, Ciranna, Lucia, Catania, Maria Vincenza, Frick, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653653/
https://www.ncbi.nlm.nih.gov/pubmed/29062097
http://dx.doi.org/10.1038/s41467-017-01191-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653653/
https://www.ncbi.nlm.nih.gov/pubmed/29062097
http://dx.doi.org/10.1038/s41467-017-01191-2

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