Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanism...

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Detalles Bibliográficos
Autores principales: Wong, Emily S., Schmitt, Bianca M., Kazachenka, Anastasiya, Thybert, David, Redmond, Aisling, Connor, Frances, Rayner, Tim F., Feig, Christine, Ferguson-Smith, Anne C., Marioni, John C., Odom, Duncan T., Flicek, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653656/
https://www.ncbi.nlm.nih.gov/pubmed/29061983
http://dx.doi.org/10.1038/s41467-017-01037-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653656/
https://www.ncbi.nlm.nih.gov/pubmed/29061983
http://dx.doi.org/10.1038/s41467-017-01037-x

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