hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a novel in vitro platform for pre-clinical cardiotoxicity and pro-arrhythmia screening of drugs in development. To date hiPSC-CMs used for cardiotoxicity testing display an immature, fetal-like cardiomyocyte structural and...

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Detalles Bibliográficos
Autores principales: da Rocha, André Monteiro, Campbell, Katherine, Mironov, Sergey, Jiang, Jiang, Mundada, Lakshmi, Guerrero-Serna, Guadalupe, Jalife, José, Herron, Todd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653750/
https://www.ncbi.nlm.nih.gov/pubmed/29061979
http://dx.doi.org/10.1038/s41598-017-13590-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653750/
https://www.ncbi.nlm.nih.gov/pubmed/29061979
http://dx.doi.org/10.1038/s41598-017-13590-y

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