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An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies
Plasmodium vivax invasion into human reticulocytes is a complex process. The Duffy binding protein (DBP) dimerization with its cognate receptor is vital for junction formation in the invasion process. Due to its functional importance, DBP is considered a prime vaccine candidate, but variation in B-c...
Autores principales: | Ntumngia, Francis B., Pires, Camilla V., Barnes, Samantha J., George, Miriam T., Thomson-Luque, Richard, Kano, Flora S., Alves, Jessica R. S., Urusova, Darya, Pereira, Dhelio B., Tolia, Niraj H., King, Christopher L., Carvalho, Luzia H., Adams, John H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653783/ https://www.ncbi.nlm.nih.gov/pubmed/29062081 http://dx.doi.org/10.1038/s41598-017-13891-2 |
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