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High-frequency, low-coverage “false positives” mutations may be true in GS Junior sequencing studies
The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufactur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653793/ https://www.ncbi.nlm.nih.gov/pubmed/29062110 http://dx.doi.org/10.1038/s41598-017-13116-6 |