The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

The human ABC transporter ABCG2 (Breast Cancer Resistance Protein, BCRP) is implicated in anticancer resistance, in detoxification across barriers and linked to gout. Here, we generate a novel atomic model of ABCG2 using the crystal structure of ABCG5/G8. Extensive mutagenesis verifies the structure...

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Detalles Bibliográficos
Autores principales: Khunweeraphong, Narakorn, Stockner, Thomas, Kuchler, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653816/
https://www.ncbi.nlm.nih.gov/pubmed/29061978
http://dx.doi.org/10.1038/s41598-017-11794-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653816/
https://www.ncbi.nlm.nih.gov/pubmed/29061978
http://dx.doi.org/10.1038/s41598-017-11794-w

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