Arrhythmogenic cardiomyopathy related DSG2 mutations affect desmosomal cadherin binding kinetics

Cadherins are calcium dependent adhesion proteins that establish the intercellular mechanical contact by bridging the gap to adjacent cells. Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (rig...

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Detalles Bibliográficos
Autores principales: Dieding, Mareike, Debus, Jana Davina, Kerkhoff, Raimund, Gaertner-Rommel, Anna, Walhorn, Volker, Milting, Hendrik, Anselmetti, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653825/
https://www.ncbi.nlm.nih.gov/pubmed/29062102
http://dx.doi.org/10.1038/s41598-017-13737-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653825/
https://www.ncbi.nlm.nih.gov/pubmed/29062102
http://dx.doi.org/10.1038/s41598-017-13737-x

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