FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition

FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast sugg...

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Detalles Bibliográficos
Autores principales: Barthelemy, Céline, Barry, Abdoulaye Oury, Twyffels, Laure, André, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653847/
https://www.ncbi.nlm.nih.gov/pubmed/29062000
http://dx.doi.org/10.1038/s41598-017-14124-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653847/
https://www.ncbi.nlm.nih.gov/pubmed/29062000
http://dx.doi.org/10.1038/s41598-017-14124-2

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