A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates. A major challenge in studying this receptor is that the mouse ortholog does not have significant affinity for antagonists that...

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Detalles Bibliográficos
Autores principales: Sergeev, Eugenia, Hansen, Anders Højgaard, Bolognini, Daniele, Kawakami, Kouki, Kishi, Takayuki, Aoki, Junken, Ulven, Trond, Inoue, Asuka, Hudson, Brian D., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653858/
https://www.ncbi.nlm.nih.gov/pubmed/29061999
http://dx.doi.org/10.1038/s41598-017-14096-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653858/
https://www.ncbi.nlm.nih.gov/pubmed/29061999
http://dx.doi.org/10.1038/s41598-017-14096-3

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