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The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

The non-receptor tyrosine kinase LCK belongs to the SRC family of kinases. SRC family kinases are proto-oncogenes that have long been known to play key roles in cell proliferation, motility, morphology and survival. Here we show that LCK regulates the function of the type III receptor tyrosine kinas...

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Detalles Bibliográficos
Autores principales: Marhäll, Alissa, Kazi, Julhash U., Rönnstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653865/
https://www.ncbi.nlm.nih.gov/pubmed/29062038
http://dx.doi.org/10.1038/s41598-017-14033-4