Cargando…

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

The homeostasis of iron is vital to human health, and iron dyshomeostasis can lead to various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway. IRPs can bind to RNA stem-loops containing an IRE in the untran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Zhi Dong, Tan, Eng-King
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654065/ https://www.ncbi.nlm.nih.gov/pubmed/29061112 http://dx.doi.org/10.1186/s13024-017-0218-4

Ejemplares similares

Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1
por: Khan, Mateen A., et al.
Publicado: (2017)

Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach
por: Khan, Mateen A., et al.
Publicado: (2023)

A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice
por: Charlebois, Edouard, et al.
Publicado: (2022)

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow
por: Bonadonna, Michael, et al.
Publicado: (2022)

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles
por: Yanatori, Izumi, et al.
Publicado: (2021)

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity
por: Wang, Jian, et al.
Publicado: (2008)

Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions
por: Khan, Mateen A., et al.
Publicado: (2014)

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5
por: Terzi, Erdem M., et al.
Publicado: (2021)

The IRP/IRE system in vivo: insights from mouse models
por: Wilkinson, Nicole, et al.
Publicado: (2014)

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
por: Casarrubea, D., et al.
Publicado: (2013)

Tumorigenic Properties of Iron Regulatory Protein 2 (IRP2) Mediated by Its Specific 73-Amino Acids Insert
por: Maffettone, Carmen, et al.
Publicado: (2010)

Association of Pro-Inflammatory Cytokines and Iron Regulatory Protein 2 (IRP2) with Leishmania Burden in Canine Visceral Leishmaniasis
por: do Nascimento, Paulo Ricardo Porfírio, et al.
Publicado: (2013)

The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis
por: Hognon, Cécilia, et al.
Publicado: (2021)

Iron-responsive-like elements and neurodegenerative ferroptosis
por: Rogers, Jack T., et al.
Publicado: (2020)

Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome
por: Luscieti, Sara, et al.
Publicado: (2013)

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice
por: Jeong, Suh Young, et al.
Publicado: (2011)

Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner
por: Gu, Wen, et al.
Publicado: (2022)

Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element
por: Tumban, Ebenezer, et al.
Publicado: (2009)

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
por: Niu, Li, et al.
Publicado: (2018)

Iron enhances the binding rates and translational efficiency of iron responsive elements (IREs) mRNA with initiation factor eIF4F
por: Khan, Mateen A., et al.
Publicado: (2021)

Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells
por: Jiao, Qian, et al.
Publicado: (2019)

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments
por: Zumbrennen-Bullough, Kimberly B., et al.
Publicado: (2014)

Iron Transport through Ferroportin Is Induced by Intracellular Ascorbate and Involves IRP2 and HIF2α
por: Scheers, Nathalie, et al.
Publicado: (2014)

Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells
por: Haro, Kurtis J., et al.
Publicado: (2012)

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders
por: Wong, Bruce X., et al.
Publicado: (2014)

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
por: Santos, Maria C. Ferreira dos, et al.
Publicado: (2020)

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer
por: Wu, Yuting, et al.
Publicado: (2023)

Kumatakenin inhibited iron-ferroptosis in epithelial cells from colitis mice by regulating the Eno3-IRP1-axis
por: Arenbaoligao,, et al.
Publicado: (2023)

Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium Diarrhea by Modulating Iron Homeostasis and Oxidative Stress via the IRP2 Pathway
por: Chen, Keyuan, et al.
Publicado: (2023)

Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling
por: Cohen, Nir, et al.
Publicado: (2017)

The physiological functions of iron regulatory proteins in iron homeostasis - an update
por: Zhang, De-Liang, et al.
Publicado: (2014)

Novel Characteristics of Immune Responsive Protein IRP30 in the Bumble Bee Bombus lantschouensis (Hymenoptera: Apidae)
por: Dong, Jie, et al.
Publicado: (2020)

Chromatin Isolation by RNA Purification (ChIRP)
por: Chu, Ci, et al.
Publicado: (2012)

SIREs: searching for iron-responsive elements
por: Campillos, Monica, et al.
Publicado: (2010)

Conservation in the Iron Responsive Element Family
por: Volz, Karl
Publicado: (2021)

Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2
por: Tsuji, Yoshiaki
Publicado: (2023)

Effect of an acute exercise on early responses of iron and iron regulatory proteins in young female basketball players
por: Cichoń, Justyna, et al.
Publicado: (2022)

Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET
por: Huynh, Nhan, et al.
Publicado: (2019)

Targeting gasdermin E in neurodegenerative diseases
por: Zhou, Zhi Dong, et al.
Publicado: (2023)

Translational control of the interferon regulatory factor 2 mRNA by IRES element
por: Dhar, Debojyoti, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_554vulnr0bvhfskqirt2g1gsup